Inflammatory Bowel Disease
Crohn’s disease and ulcerative colitis may have a connection to psoriasis. One study found that 1 in 10 women with psoriasis also has a form of inflammatory bowel disease. Two of the biologic drugs used to treat psoriasis can cause these illnesses or make them worse. If you’re affected by this, talk with your doctor before you try secukinumab (Cosentyx) or ixekizumab (Talz).
When you take a psoriasis treatment drug that slows down your immune system, like cyclosporine, methotrexate, or biologic drugs, your body can’t fight off infection like it normally would. If you have an active serious infection, you shouldn’t take these. You should also be tested to see if you’ve been exposed to tuberculosis or are carrying hepatitis B. Many antibiotics that treat infections shouldn’t be taken with systemic drugs. Some change how well your body absorbs the psoriasis treatment drug. Others keep your kidneys from flushing the medicine from your system. That can let it build up to dangerous levels.
People who have psoriasis are twice as likely to be depressed as people who don’t have it. Psoriasis treatment can improve your mood. But one psoriasis medication, apremilast, may make depression worse.